Okonkwo UA, Chen L, Ma D, et al. - Using a mouse model diabetes, researchers investigated the effects of diabetes on wound maturation, and in particular, the state of the capillary bed as healing resolves. MicroCT analysis of the 3-dimensional architecture of the capillary bed was performed using a mouse model of diabetic wound healing. Comparison was performed with wild type (WT) mice. Wounds of mice with diabetes vs WT mice showed significantly decreased vessel surface area, branch junction number, total vessel length, and total branch number. Further, there was significantly increased capillary permeability and decreased pericyte coverage of capillaries in wounds of mice with diabetes. Wounds of mice with diabetes showed significantly reduced expression of pro-angiogenic factors and factors responsible for pericyte recruitment and vessel maturation. In wounds of mice with diabetes, specifically, they observed down-regulation of the expression of VEGF-A, Sprouty2, PEDF, LRP6, Thrombospondin 1, CXCL10, CXCR3, PDGFR-β, HB-EGF, EGFR, TGF-β1, Semaphorin3a, Neuropilin 1, angiopoietin 2, NG2, and RGS5.