Lange T, et al. - Considering the ubiquitous involvement of thyroid hormones in human metabolism, researchers sought for the precise molecular patterns associated with alterations in thyroid hormones levels in detail. They ascertained the association between free thyroxine (FT4) or thyrotropin and metabolite levels among 952 participants in the Study of Health in Pomerania. They identified a significant association of 106 of 613 plasma metabolites with FT4 after accounting for major confounders. Thyroid hormones were confirmed to have the lipolytic and lipogenic effect even in the physiological range. Observations revealed different phenotypic characteristics (eg, lifestyle differences) as possible confounders for sex-specific findings.