In view of the greatest burden of the HIV/AIDS epidemic shared by women of reproductive age in sub-Saharan African (SSA), researchers herein sought to examine the comprehensive knowledge concerning HIV/AIDS and linked factors among women of reproductive age in sub-Saharan Africa.

• Data from the most recent SSA countries Demographic and Health Surveys (DHS) were used.

• A composite score of six separate questions (can get HIV by witchcraft or supernatural means, can reduce risk of getting HIV by using condoms during sex, reduce the risk of getting HIV by having one sex partner only, can get HIV from mosquito bites, can get HIV by sharing food with a person who has HIV/AIDS, and a healthy-looking person can have HIV) was utilized for assessing comprehensive knowledge.

• The comprehensive knowledge concerning HIV/AIDS was 38.56%, indicating a low comprehensive knowledge of HIV/AIDS in this population.

• Researchers identified correlation of both individual and community-level factors with comprehensive knowledge of HIV/AIDS.

• Higher odds of comprehensive knowledge about HIV/AIDS were recorded in correlation with following individual-level factors: older age, having primary and above educational level, being from wealthy households, contraceptive use, listening to the radio, and reading newspapers.

• Following were the community-level factors linked with higher odds of comprehensive knowledge about HIV/AIDS: being from urban areas and the Eastern African region.

• These findings emphasize giving special attention to those young women, women who had no formal education, those from poor socioeconomic status, and those who are from remote areas in order to decrease the epidemics of HIV/AIDS by improving the comprehensive knowledge about HIV/AIDS.

• Besides, researchers emphasize strengthening media campaigns regarding HIV/AIDS to enhance comprehensive knowledge about HIV/AIDS.