Zhang N, et al. - Researchers sought to determine the interaction mechanism of key RNAs and their regulatory network in childhood acute myeloid leukemia (AML). From the Therapeutically Applicable Research to Generate Effective Treatment database, they downloaded RNA profiles and identified specific lncRNAs, miRNAs, and mRNAs in high-risk group of childhood AML. A lncRNA-mRNA-miRNA ceRNA network in childhood AML was constructed incorporating 13 lncRNAs, 7 miRNAs, and 67 mRNAs. As per the functional analysis, these DEmRNAs were noted to be significantly enriched in Ras signaling pathway, TGF-beta signaling pathway, and other tumor-related pathways. Among the network, they observed an association of 10 RNAs (LINC00471, hsa-mir-100, hsa-mir-150, ANP32E, ERMP1, MYO1B, PAPD7, PTGIS, TERF1, and VEGFA) with high-risk group of childhood AML and significance of functions for prognosis. Together these findings render a new insight into the pathogenesis of high-risk group of childhood AML that may help clinicians clarify the function of lncRNA to guide the treatment and in-depth study.