Chen J, Tang H, Li T, et al. - Researchers sought to determine the expression of OVOLs (OVO-like proteins; universally conserved genes encoding C2H2 zinc finger transcription factors in mammals) in breast cancer (BRCA) tissues as well as their value in prognosis. They used ONCOMINE to assess the expressions of OVOL1, OVOL2, and OVOL3 mRNA between BRCA tissues and normal breast tissues. A significantly higher expression of OVOL1/2 was detected in BRCA tissues vs in normal breast tissues. A correlation of OVOL3 expression with tumor stage was identified. The AUC of OVOLs was reported to be 0.757, 0.754, and 0.537, respectively. A shorter overall survival was observed in relation to OVOL1 high expression. Overall, OVOL1 was identified as a new potential marker of prognosis in BRCA, and experts concluded the utility of OVOL1/2 as potential treatment targets in BRCA.