MacArthur KM, Baumann BC, Sobanko JF, et al. - Since sentinel lymph node biopsy (SLNB) for invasive melanomas treated with Mohs micrographic surgery using frozen-section MART-1 immunohistochemical stains (MMS-IHC) has not been studied, researchers sought to evaluate the accuracy and compliance with National Comprehensive Cancer Network guidelines for SLNB in a cohort of patients with invasive melanoma treated with MMS-IHC. Between March 2006 and April 2018, all patients who had primary, invasive, cutaneous melanomas treated with MMS-IHC at a single academic center were included. A total of 667 primary, invasive, cutaneous melanomas (American Joint Committee on Cancer T1a-T4b) were treated with MMS-IHC. According to this retrospective cohort study, the combination of SLNB and MMS-IHC allows for complete pathologic staging and confirmation of clear microscopic margins before reconstructing specialty site invasive melanomas. SLNB can be performed accurately and in accordance with consensus guidelines in melanoma patients using MMS-IHC.