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Complete response on MR imaging after neoadjuvant chemotherapy in breast cancer patients: Factors of radiologic-pathologic discordance

European Journal of Radiology Aug 26, 2019

Choi WJ, Kim HH, Cha JH, et al. - In this retrospective analysis, researchers examined breast cancer patients (n = 209) who showed radiologic complete response (rCR) in MR imaging following neoadjuvant chemotherapy to assess the radiologic and clinicopathologic factors in radiologic-pathologic discordance (false-negative results). The diagnosis of rCR was made when no enhancement was demonstrated by the original lesion site. Among the participants, the factors found to be significantly related to false-negative results were calcification in mammography, multifocal multicentric lesions, and non-mass enhancement in pretreatment MR imaging. A significantly high false negative rate when assessing rCR after NAC was associated with the luminal breast cancer subtype. Exercising caution was recommended while interpreting these patient populations..

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