Tabacco S, Giannini A, Garufi C, et al. - In this study, experts ascertained the accurate mechanism through which complement mediates antiphospholipid syndrome (an acquired thrombophilic disease, diagnosed by the persistent presence of antiphospholipid antibodies like lupus anticoagulant, anticardiolipin antibodies, and anti-beta 2 GP1 in cases with vascular thrombosis and/or pregnancy morbidity) complications. Low complement levels (C3 and C4) were discovered to be correlated with poor pregnancy outcomes in women with antiphospholipid syndrome in various studies. Hypocomplementemia could be designated as an advanced predictor of adverse pregnancy outcome, available at the commencement of pregnancy for starting if needed, supplementary treatment to conventional therapy. Nevertheless, future studies require to thoroughly understand the influence of low complement level on antiphospholipid syndrome pregnancy outcome.