Competing‐risks model for prediction of small‐for‐gestational‐age neonate from biophysical and biochemical markers at 11–13 weeks' gestation
Ultrasound in Obstetrics & Gynecology Dec 14, 2020
Papastefanou I, Wright D, Syngelaki A, et al. - In this prospective observational study, researchers developed a new competing‐risks model for the prediction of a small‐for‐gestational‐age (SGA) neonate, based on maternal factors and biophysical and biochemical markers at 11–13 weeks of gestation. The sample consisted of 60,875 women with singleton pregnancy undergoing routine ultrasound examination at 11 + 0 to 13 + 6 weeks' gestation. All pregnancies had plasma protein‐A and placental growth factor (PlGF) measurements associated with pregnancy, 59,001 had uterine artery pulsatility index (UtA‐PI) measurements and 58 479 had mean arterial pressure measurements; 57,131 cases had complete data for all biomarkers. According to findings, UtA-PI was the best biophysical indicator of preterm SGA and PlGF was the best biochemical marker. This research provided a single continuous two-dimensional model for predicting SGA for any desired cut‐offs of smallness and GA at delivery, laying the ground for a personalized antenatal plan for predicting and managing SGA, in the milieu of a new inverted pyramid of prenatal care.
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