Odenthal J, et al. - Given that detection of the tumor and its margin are improved with new approaches based on fluorescence-guided surgery (FGS), researchers examined the compatibility of fluorophores with high-power laser application. In addition, they determined if precision is compromised by laser-induced bleaching of the dye. Topology-controlled 3D laser resection of fluorescent tumors cell was applied in vitro and laser-induced autofluorescence analysis was applied ex vivo. Observations revealed negligible laser-induced lateral photobleaching. This suggests a path forward for fluorescence-guided laser surgery in head and neck cancer.