Ohno Y, et al. - Experts attempted to compare the capability of xenon-enhanced area-detector CT (ADCT) performed with a subtraction technique and coregistered ^81mKr–ventilation SPECT/CT for the determination of pulmonary functional loss and disease severity in smokers. When compared to ^81mKr–ventilation SPECT/CT, xenon-enhanced ADCT was discovered to be more effective for the analysis of pulmonary functional loss and disease severity.