Zhao Q, Cheng YJ, Xu YK, et al. - The triglyceride-glucose (TyG) index, which is most strongly linked to the risk of major adverse cardiovascular and cerebrovascular events (MACCE), can be served as the most valuable insulin resistance (IR) surrogate for risk prediction and stratification in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients having percutaneous coronary intervention (PCI), with and without type 2 diabetes mellitus (T2DM).

• Two thousand one hundred seven individuals (60.02 ± 9.03 years, 28.0% female) were eventually recruited in the current study.

• During the 24-month follow-up, a total of 187 (8.9%) MACCEs were documented.

• Regardless of whether the lower median was used as a reference or 1 normalized unit increase was considered, the TyG index remained the best risk predictor for MACCE, independent of confounding factors.

• The TyG index provided the most powerful diagnostic value for MACCE, with a value of 0.715 for the area under the receiver operating characteristic curve.

• When compared with other IR surrogates, the addition of the TyG index resulted in the greatest improvement in risk categorization for MACCE on the basis of a baseline model.

• The results were consistent in subgroup analysis, where identical analyses were done in patients with and without T2DM, respectively.