Paul M, et al. - In view of the recommendation of using short-acting agents for sedation during targeted temperature management (TTM) after cardiac arrest (CA), researchers here sought for the potential advantages of this strategy. Two sedation regimens (propofol-remifentanil, period P2, vs midazolam-fentanyl, period P1) among comatose TTM-treated CA survivors were compared. They noted that sedation with propofol-remifentanil during TTM following resuscitation from CA was associated with significantly earlier awakening and more ventilator-free days as compared with midazolam-fentanyl.