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Comparison of two major staging systems in predicting survival and recommendation of postoperative radiotherapy based on the 11th Japanese classification for esophageal carcinoma after curative resection: A propensity score-matched analysis

Annals of Surgical Oncology May 16, 2021

Chang X, Deng W, Ni W, et al. - This study was attempted to correlate the prognostic predictive power of the 11th Japan Esophageal Society (JES) staging system with the 8th edition of the American Joint Committee on Cancer (AJCC) staging system in patients with thoracic esophageal squamous cell carcinoma and to estimate the survival benefits of postoperative radiotherapy (PORT) based on a substage of the JES staging system. Researchers performed propensity score matching (PSM) analysis to balance the two groups (surgery only [S group] or surgery plus PORT [S+RT group]) across substages of the 11th JES staging system according to independent prognostic factors for overall survival distinguished using Cox proportional hazards regression. A total of 2,960 individuals were included in the study. Compared with the 8th AJCC staging system, the 11th JES staging system was less capable of predicting prognosis, and patients in stage III of the JES staging system were highly recommended to undergo PORT.

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