Song J, et al. - In patients with a chronic viral liver disease, researchers compared the three most widely used cut-off values (around 13.6 kPa, 18 kPa and 22kPa) of transient elastography-based liver stiffness value (TE-LSV) for the diagnosis of clinically significant portal hypertension (CSPH). They searched PubMed, Ovid, Web of Science and Cochrane Library databases. The results obtained from this meta-analysis indicate that in the diagnosis of CSPH, cut-off values around 13.6 kPa (high sensitivity) and 22 kPa (high specificity) could be used as screening and confirmation tools, respectively. It was observed in the findings that the cut-off value around 22 kPa exhibited the best performance.