Wang C, He W, Yuan Y, et al. - Among retrospectively enrolled 580 patients with early recurrent hepatocellular carcinoma (HCC) (ErHCC, within 2 years post-hepatectomy), researchers compared the prognostic significance of inflammation-based prognostic scores for post-recurrence survival (PRS). They used Cox regression to assess the link between the independent baseline and the time-dependent variables and PRS. They found that the Glasgow Prognostic Score, modified Glasgow Prognostic Score, Prognostic Index, Prognostic Nutritional Index, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, lymphocyte to monocyte ratio and systemic immune-inflammation index (SII) were all associated with the PRS of ErHCC patients, while PRS was independently predicted only by the SII in multivariate analysis. Overall, findings revealed the usefulness of the SII as a prognostic indicator for PRS in patients with ErHCC post-hepatectomy. Also, the results demonstrated its superiority over other inflammation-based prognostic scores in terms of prognostic ability.