Rodriguez AM, Zeybek B, Vaughn M, et al. - In this retrospective matched cohort study, researchers intended to determine if there is a connection between the number of human papillomavirus (HPV) vaccine doses and the risk of histologically confirmed preinvasive cervical disease and high-grade cytology. Using administrative data from Optum's Clinformatics DataMart Database, they identified females (aged 9 to 26 years) who received one or more quadrivalent HPV vaccine doses between January 2006 and June 2015. Participants in the study were 133,082 females (66,541 vaccinated and 66,541 unvaccinated) stratified by the number of HPV vaccine doses and the vaccine initiation age. According to findings, the receipt of 1, 2, or 3 doses of an HPV vaccine by females (aged 15 to 19 years) was linked to a lower incidence of preinvasive cervical disease compared with unvaccinated females, and this encourages the use of any HPV vaccination to reduce the burden of the disease.