Hanumanthu V, Thakur V, Narang T, et al. - According to this prospective randomized clinical trial, minocycline demonstrated superior efficacy to clofazimine in terms of rapid and sustained improvement of erythema nodosum leprosum (ENL) episodes with fewer adverse events.

• The sample consisted of 60 participants with chronic/recurrent ENL.

• Participants in the study were randomly assigned (1:1) to receive either minocycline 100 mg once daily or clofazimine 100 mg thrice daily for 12 weeks along with prednisolone according to WHO protocol, and they were followed up for 6 months.

• When compared with the clofazimine group, the minocycline group achieved initial control of ENL sooner.

• During the study period, the number of participants experiencing ENL flares/recurrences was comparable in both groups.

• When compared with the clofazimine group, participants in the minocycline group remained in remission for a longer period of time after the initial control of ENL.

• In both groups, the mean additional prednisolone dose required to control ENL flares/recurrences was comparable.

• There were fewer side effects in the minocycline group than in the clofazimine group.