Edvardsson VO, et al. - A comparative scrutiny was carried out of the effect of xanthine oxidoreductase inhibitors allopurinol and febuxostat on urinary 2,8-dihydroxyadenine (DHA) excretion in adenine phosphoribosyltransferase (APRT) deficiency patients. The results disclosed a decrease in the urinary DHA excretion with conventional doses of both allopurinol and febuxostat. Nevertheless, febuxostat was markedly more efficacious than allopurinol in reducing DHA excretion in the prescribed doses. This, in turn, possibly depicted improved outcomes of patients with APRT deficiency.