Sharif S, et al. - Researchers performed a comparison of the efficacy and safety of using age-adjusted D-dimer interpretation, clinical probability-adjusted D-dimer interpretation and standard D-dimer approach in excluding pulmonary embolism (PE) in Emergency Department (ED) patients. A health records review was planned at two Emergency Departments over a two-year period to assess all cases where patients had a D-dimer ordered to test for PE or underwent CT or VQ scanning for PE. As per findings, exclusion of PE could be made using the clinical probability-adjusted rule in a greater proportion of patients, with a very small reduction in the negative predictive value.