Schneider AF, Stocker D, Hötker AM, et al. - In this single-center, retrospective cohort study, researchers contrasted the association of transition zone prostate-specific antigen density (TZPSAD) vs whole gland (WG) density (PSAD) with Gleason score. Participants in the study were 178 men (median age 64 y, interquartile range 58-68 y; PSA 6.6 ng/ml, 4.6-9.7 ng/ml) undergoing MRI of the prostate in 2015 and 2016 who had a transperineal template saturation biopsy within 6 months of MRI. According to findings, the TZPSAD displayed a stronger relationship with cancer dedifferentiation than PSAD and could, therefore, be a better cancer aggressiveness surrogate marker than PSAD. In addition, the TZPSAD threshold of 0.22 ng/ml² can assist men with suspected PCa in risk stratification.