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Comparison of pregnancy outcomes between women with early-onset and late-onset gestational diabetes in a retrospective multi-institutional study in Japan

Journal of Diabetes Investigation Jun 23, 2019

Usami T, et al. - In this multi-institutional retrospective study involving data from 600 early and 881 late group participants, researchers compared pregnancy outcomes between women with gestational diabetes (GDM) diagnosed early and late in pregnancy in Japan. Study participants were women diagnosed with GDM and divided into 2 groups by gestational age at diagnosis: <24 weeks of gestation (early group, 14.4 ± 4.2 weeks) and ≥24 weeks of gestation (late group, 29.6 ± 3.4 weeks). Although in the early group pre-pregnancy body mass index was higher than in the late group, in the early group gestational weight gain was lower. Investigators found that maternal complications were higher in the early group than in the late group, including hypertensive disorders of pregnancy and cesarean delivery. Earlier GDM intervention can be linked to a decrease in large-for-gestational-age infants. No significant difference was found in other neonatal adverse outcomes between the groups.
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