Park GE, et al. - A total of 469 cases from 444 women with pathologically confirmed suspicious calcifications from January 2012 to June 2016 were recruited in a retrospective study by the researchers in order to assess variations in the positive predictive value (PPV) of categorization of suspicious calcification for malignancy with the 4th vs the 5th edition of BI-RADS. The PPVs of categorization using the 5th edition matched better with BI-RADS category evaluation in comparison with categorization using the 4th edition. The PPVs of morphology were amorphous, 15.9%; coarse heterogeneous, 31.7%; fine pleomorphic, 58.2%; and fine linear or branching, 90.6%. The PPVs of distribution were regional, 31.5%; grouped, 31.3%; linear, 50%; and segmental, 77.9%. Distribution influenced the PPVs and categorization of coarse heterogeneous, fine pleomorphic, and fine linear or branching calcifications when distribution was classified into two types (grouped or regional vs segmental or linear) and investigated in combination with suspicious morphology. Thus, to stratify risk levels of areas of suspicious calcification, categorization using both morphology and distribution according to the BI-RADS 5th edition was beneficial.