Jiang YL, Zhang RC, Zhou, YC, et al. - By analyzing eight relevant studies identified from PubMed, EMBASE, Web of Science, ClinicalTrials.gov and the Cochrane Central Register with 15,278 patients, researchers compared laparoscopic pancreaticoduodenectomy (LPD) with open pancreaticoduodenectomy (OPD) with respect to oncological results and clinical effectiveness in patients with pancreatic ductal adenocarcinoma. Studies published between May 1998 and May 2018 were included. Analysis of oncological outcomes and perioperative data was carried out. With regard to 5-year overall survival, LPD was found to be equal to OPD in these patients. Better perioperative clinical outcomes were achieved with LPD, which resulted in similar rates of postoperative pancreatic fistulas and postoperative hemorrhage, more harvested lymph nodes, shorter hospital stays, and less estimated blood loss vs OPD.