Shavelle DM, et al. - Researchers used the PROTECT II randomized trial and the cVAD Registry to compare clinical outcomes in patients with and without previous coronary artery bypass grafting (CABG) and multi-vessel coronary artery disease or unprotected left main (LM) disease and severely reduced left ventricular systolic function undergoing Impella supported percutaneous coronary intervention (PCI). Overall mortality at 30 days was the prime focus of this analysis. No association of prior CABG surgery with worse outcome was observed in this high-risk cohort of patients undergoing hemodynamically supported PCI. The increased risk of PCI related to prior CABG appeared to be mitigated by using hemodynamic support.