Yan CH, et al. - Experts compared the outcomes of culture-directed antibiotics vs non-culture-directed antibiotics for treatment of chronic rhinosinusitis (CRS). They examined a total of 946 CRS patients treated with antibiotics; 122 CRS patients with acute exacerbations were treated with culture-directed vs empiric antibiotics. Long-term endoscopy scores were improved with culture-directed therapy but an advantage in improving short-term endoscopy scores or an improvement in the short-term and long-term quality of life scores in CRS patients were not yielded by this therapy.