Choi M, Youn HC, Kim D, et al. - Given that Alzheimer disease (AD)-related neurodegeneration could be assessed using several metrics of analysis of MRI, researchers conducted a comparison of four structural brain MRI analysis metrics (cortical thickness, volume, surface area, and local gyrification index [LGI]) in different phases of AD-related cognitive decline using Mini Mental State Examination (MMSE)/Consortium to Establish a Registry for Alzheimer Disease (CERAD) total scores and 68 regions of interest (ROIs). Findings suggest links and inter-relations of the morphometric measures, however, there are differences in the types of descending graphs and significant ROIs for the various measures considered in this study. Cortical thickness analysis seemed more favorable in evaluating brain structural MRI changes of individuals with AD-related cognitive decline, however, there appeared limited capability of LGI analysis in reflecting cognitive decrease. Moreover, compared to MMSE scores, CERAD total scores were identified as more sensitive to early changes of cortical structures.