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Comparison of nalbuphine, ondansetron and placebo for the prevention of shivering after spinal anaesthesia for urgent caesarean delivery: A randomised double-blind controlled clinical trial

International Journal of Obstetric Anesthesia Oct 31, 2019

Liu J, et al. - Among parturients undergoing urgent caesarean delivery, researchers investigated whether post-spinal anaesthesia shivering could be prevented by prophylactic nalbuphine and ondansetron. They identified 60 parturients scheduled for urgent caesarean delivery prior to spinal anaesthesia, and grouped them randomly into three groups. Parturients received peripheral venous catheterisation, thereafter, were administered intravenous nalbuphine 0.08 mg/kg (group N), ondansetron 8 mg (group O), or normal saline (group C). They found that group N had significantly lower incidence of shivering and severe (grade ≥ 3) shivering vs group C prior to delivery. In the first 30 min post-anaesthesia, group N vs group C experienced significantly less shivering. Overall, findings revealed the ability of nalbuphine 0.08 mg/kg in preventing post-spinal anaesthesia shivering in parturients undergoing urgent caesarean delivery, however, transient dizziness associated with its use was reported. No significant effect of ondansetron 8 mg was evident.
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