Lan XW, et al. - By analyzing 1816 pathological stage T1-2N1M0 breast cancer patients, researchers compared radiotherapy (RT) after BCS and postmastectomy RT in terms of long-term outcomes in stage T1-2N1M0 breast cancer. They selected 196 pairs of patients between BCS and mastectomy receiving postoperative RT, using propensity score matching method. The endpoints were five-year locoregional relapse (LRR), locoregional relapse-free survival (LRFS), distant metastasis (DM), distant metastasis-free survival (DMFS), disease-free survival (DFS), and breast cancer-specific survival (BCSS). In T1-2N1M0 breast cancer, remarkably improved survival was achieved with postoperative RT but no such improvement was evident in the mastectomy subgroup, except for LRR and LRFS. Better survival was experienced by patients with BCS plus RT vs those with postmastectomy radiation in terms of DM, DMFS, DFS and BCSS.