Lee JM, Rhee TM, Kim HK, et al. - Researchers used the nationwide, multicenter, prospective KAMIR-NIH (Korea Acute Myocardial Infarction Registry––National Institutes of Health) registry, to compare 3-year clinical outcomes between multivessel percutaneous coronary intervention (PCI) vs infarct-related artery (IRA)–only PCI for patients with ST-segment-elevation myocardial infarction multivessel disease with cardiogenic shock. All-cause death was the primary outcome. Multivessel PCI and IRA-only PCI were done in 260 patients and 399 patients, respectively. Lower risk of recurrent myocardial infarction and non-IRA repeat revascularization beyond 1 year was observed in the multivessel PCI group vs the IRA-only PCI group, as revealed in landmark analysis at 1 year. Findings revealed a lower risk of all-cause death at 3 years in relation to multivessel PCI vs IRA-only PCI among patients with ST-segment-elevation myocardial infarction and cardiogenic shock. This indicates the potential advantage of non-IRA revascularization during the index hospitalization to better long-term clinical results.