Dehghanpisheh L, Eghbal M, Baravati FB, et al. - Researchers undertook this prospective randomized controlled trial study to compare the impact of decreasing cough reflex post-injection of fentanyl in a fusion protocol by integrating the injections of lidocaine and Huffing maneuver and comparing with a placebo control group, prior to anesthesia induction. Participants included 400 patients. These were split into four groups: combined protocol (group 1), lidocaine group (group 2), Huffing maneuver group (group 3), and the control receiving normal saline (group 4). Patients were delivered injections with 2. 5 μg /kg fentanyl and monitoring was performed for 2 min with respect to their cough reflex, and the severity. Findings indicated that better outcomes, in terms of decreasing the frequency, and also the severity of cough followed by fentanyl injection, can be achieved by using a combination of lidocaine injection along and Huffing maneuver.