Mac–Marcjanek K, et al. – In this study, researchers revised this linkage by evaluating leukocyte IL6 expression and its correlations with clinical characteristics of patients diagnosed by the Polish Diabetes Association (PDA) 2011 and 2014 criteria. It was demonstrated that differences in metabolic phenotypes as well as gene expression and correlation data between GDM and NGT groups, categorised based on PDA 2011 and 2014 criteria, are related to changes in gestational glucose tolerance status resulting from using PDA 2014 criteria. Furthermore, the outcomes support the hypothesis that IL–6 is correlated with glucose metabolism during pregnancy.

Methods

• For this research, a sum of of 145 pregnant women underwent 75 g two–hour OGTT, and GDM was diagnosed according to PDA 2011 criteria (GDM/PDA 2011 group; n = 113) and PDA 2014 criteria (GDM/PDA 2014 group; n = 104).
• They evaluated IL6 gene expression in leukocytes of all participants by using real–time PCR method.

Results

• Compared to respective NGT control groups, the GDM/PDA 2011 group exhibited higher FPG, two–hour OGTT, HbA1C and IL6 expression and lower HDL–C, whereas the GDM/PDA 2014 group had higher FPG, one–hour and two–hour OGTT, HbA1C and HOMA–IR, lower QUICKI–IS, and unchanged IL6 expression.
• There were no differences in metabolic parameters and IL6 expression between the two GDM groups.
• They found that the NGT/PDA 2014 group had lower one–hour and higher two–hour OGTT and increased IL6 expression when compared with the NGT/PDA 2011 group,.
• With PDA 2014 criteria, they observed that IL6 expression associated positively with two–hour OGTT in both NGT and GDM groups as well as with LDL–C in NGT group, and negatively with HDL–C in NGT group.
• No correlations were evident in NGT and GDM groups with PDA 2011 criteria.
• However, significant positive association of IL6 mRNA with two–hour OGTT was found in the entire study group.