Li D, Wang Q, Zhao X, et al. - The present study was conducted to ascertain if intravenous and topical dexamethasone (DEX) provide different clinical effects in patients with total knee arthroplasty (TKA). Researchers designed a double-blinded, placebo-controlled trial randomizing a total of 90 patients undergoing primary TKA to intravenous DEX group (n=45) or topical DEX group (n=45, DEX used in the anesthetic cocktail for periarticular injection). While intravenous DEX was more effective in decreasing blood inflammatory biomarkers and preventing postoperative nausea, it was shown that the topical administration of DEX provided better clinical outcomes on postoperative pain management and knee swelling early after TKA.