Diercks GR, et al. - In this randomized, multicenter, double-blind, noninferiority clinical trial involving 741 children, researchers studied the impact of ibuprofen vs acetaminophen on posttonsillectomy bleeding requiring surgical intervention. Findings revealed that the bleeding rate requiring operative intervention was 1.2% in the acetaminophen group and 2.9% in the ibuprofen group. In children receiving ibuprofen after tonsillectomy alone or tonsillectomy with adenoidectomy, this investigation could not exclude a higher rate of severe bleeding. When selecting a postoperative analgesic regimen, this finding should be considered.