Diercks GR, et al. - In this randomized, multicenter, double-blind, noninferiority clinical trial including 741 children, researchers examined the impact of ibuprofen vs acetaminophen on posttonsillectomy bleeding requiring surgical intervention. Data reported that the bleeding rate requiring operative intervention was 1.2% in the acetaminophen group and 2.9% in the ibuprofen group. This research could not rule out a higher rate of severe bleeding following tonsillectomy alone or tonsillectomy with adenoidectomy in children receiving ibuprofen. When choosing a postoperative analgesic regimen, this finding should be considered. No serious adverse events or deaths have occurred.