Plante TB, et al. - Researchers performed a comparison of atherosclerotic cardiovascular disease (ASCVD) events by the level of Pooled Cohort Equation (PCE)-predicted risk among primary and secondary prevention Systolic Blood Pressure Intervention Trial (SPRINT) populations. In SPRINT, adults with hypertension and ≥ 1 CVD risk factor or previous CVD events were randomized to systolic blood pressure control targeting < 120 mm Hg or 135 to 139 mm Hg. Among 8,151 participants, previous CVD was reported in 16%, the mean age was 66 years and 35% were women. Overall HR for ASCVD events was 2.51 (1.96, 3.20). As per observations, researchers suggest a potential risk for subsequent ASCVD events in correlation with the history of previous events. The PCE led to no improvement in risk prediction among secondary prevention populations and it may differentially underestimate risk in secondary prevention populations with lowest predicted risk.