Aboulatta L, Sugita H, Wakabayashi H, et al. - In view of the recommendation of alternative dosing strategies for β-lactams – the most common antibiotics employed to manage critically ill patients with respiratory tract infections – to enhance the duration of exposure and decrease drug resistance, researchers sought to evaluate if extended infusion of antipseudomonal β-lactams reduces mortality and improves clinical efficacy. This seems to be the first meta-analysis focusing on extended infusion. Searching the PubMed, Cochrane Library, Scopus, and ICHUSHI databases, nine studies involving 1,508 participants were identified for inclusion in the meta-analysis. Outcomes revealed reduced mortality rates in correlation with extended infusion. The main outcomes remained robust to subgroup analyses and sensitivity analyses. They suggest extended infusion as advantageous for reducing mortality but with no effect on clinical success.