Li Y, et al. - The present study was sought to ascertain whether positive anticentromere antibody (ACA) serology influences the severity of sicca symptoms in patients with primary Sjögren syndrome (pSS). Researchers conducted questionnaires, physical examination, and pathology to detect subjective and objective sicca symptoms. They categorized cases of pSS according to the 2002 American-European Consensus Group (AECG) criteria. They assessed all patients for presence of anti-Ro, anti-La, and ACA serology. Individuals with pSS were classified into ACA+ SS and ACA–SS. There were 446 patients in the pSS group, of whom 26 were ACA+ SS. Compared with ACA–SS, ACA+ SS is correlated with more severe objective ocular sicca and more severe subjective and objective oral sicca. For pSS, the majority of ACA+ patients with SS meet AECG criteria despite negative serology for anti-Ro/La antibodies.