Singh S, et al. - Sympathetic stimulation and increase in heart rate (HR), mean arterial pressure (MAP) and intracranial pressure (ICP) resulting from chest physiotherapy (CP) and tracheal suctioning (TS) can cause a deleterious effect in patients with a head injury. Consequently, researchers compared the impact of intravenous dexmedetomidine and lidocaine to CP and TS on intracerebral and systemic hemodynamic response in patients with severe traumatic brain injury (sTBI). In this prospective, randomized study, rise in HR, MAP and ICP in response to CP and TS in patients with sTBI could be effectively diminished with use of both dexmedetomidine and lidocaine. However, intravenous dexmedetomidine vs baseline and lidocaine caused significant decrease in MAP and CPP.