de Miguel–Gómez L, López-Martínez S, Campo H, et al. - Researchers examined how human plasma from different sources, namely, umbilical cord blood and adult blood platelet-rich plasma (PRP), affects the regeneration of endometrial damage. They designed composition analysis, in vitro approaches, and a preclinical murine model utilizing plasma to promote endometrial regeneration. They employed adult plasma from four Asherman syndrome/endometrial atrophy patients and one fertile woman, commercial umbilical cord plasma, and uterine-damaged NOD/SCID mice model. In vitro culture of endometrial stromal cells from primary culture and an endometrial stem cell line was performed, and plasma samples from several origins were used to treat uterine-damaged NOD/SCID mice. Outcomes suggest that regeneration properties are possessed by human PRP that are usable for endometrial pathologies. Besides that, when the source of obtaining is umbilical cord blood, these regenerative effects appear to be more apparent.