Comparison of different ankle-brachial indices in the prediction of overall and cardiovascular mortality
Atherosclerosis Apr 26, 2020
Hsu PC, Lee WH, Chen YC, et al. - Since no study to date has evaluated ankle-brachial index (ABI) calculated using mean artery pressure (MAP) and diastolic blood pressure (DBP) in predicting death, so, researchers undertook this inquiry, wherein, they assessed the best cutoff values of ABImbp and ABIdbp for peripheral artery disease (PAD) prediction, using a cohort of 379 patients (106 patients having angiography-confirmed PAD and 273 relative normal patients), and evaluated the ability of different ABIs in predicting death, using another cohort of 941 patients undergoing echocardiographic assessments. For PAD prediction, the best cutoff values of ABImbp and ABIdbp were estimated to be 0.92 and 0.88, respectively. In multivariable analysis, overall and cardiovascular mortality could be predicted by ABIsbp, ABImap, ABIdbp, ABIsbp < 0.9, and ABImap <0.92. A direct comparison of 6 multivariable models revealed the basic model + ABImap < 0.92 as the best model for predicting overall as well as cardiovascular mortality. Therefore, extra advantage in survival prediction might be afforded by calculation of ABI using MAP except systolic blood pressure (SBP).
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