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Comparison of coronary atherosclerotic plaque burden and composition as assessed on coronary computed tomography angiography in East Asian and European-origin Caucasians

The American Journal of Cardiology Jul 20, 2019

Ihdayhid AR, et al. - In a matched cohort of Caucasian and East Asians patients with stable chest pain who had computed tomography angiography (CTA), researchers intended to compare coronary atherosclerotic burden and plaque composition. For this investigation, 200 symptomatic patients (age 58.8±7.9) were matched for age, gender, body mass index (BMI) and diabetes (100 each ethnic group). On multivariable analysis East Asian ethnicity was independently linked to the lower composition of high-risk plaque after adjustment for risk-factors and scan parameters. Based on this matched cohort, East Asian ethnicity is correlated with a considerably reduced composition of high-risk NCP (necrotic core and fibrofatty plaque) and a greater composition of low-risk fibrous plaque relative to Caucasians, which may result in reduced cardiovascular risk.
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