Park YG et al. – This study evaluated the effectiveness of continuous infusion (CI) of factor VIII during the perioperative period of total knee arthroplasty (TKA) compared with bolus injections (BIs). In conclusion, although both methods provided a good control of hemostasis during perioperative period of TKA, CI was found to be more tolerable and effective compared with BI.

Methods

• Perioperative clinical parameters evaluated in 42 TKAs performed in 31 patients with severe hemophilia A included postoperative hemoglobin drop, drained blood volume, transfusion rate, total consumption of FVIII, and perioperative complications.

Results

• The postoperative hemoglobin drop and drained blood volume were significantly lower in the CI group compared with the BI group (P = .002 and P = .037, respectively).
• Total consumption of factor concentrates over 5 days postoperatively was significantly greater in the CI group than in the BI group (P = .0000).
• Perioperative complications reported in the study included 1 postoperative hematoma and wound dehiscence, which occurred in the BI group.