Lee YT, Wang JJ, Luu M, et al. - Researchers conducted this large retrospective study to examine the differences between intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC) in terms of demographic, socioeconomic, clinical features at presentation and treatment patterns and overall survival (OS) in the United States general population. The Surveillance, Epidemiology, and End Results Program 18 Database (2000-2017) was used to collect demographic and clinical information on HCC and iCCA patients. Logistic regression analysis was conducted to identify factors associated with iCCA diagnosis vs HCC. Diagnosis in recent years, age (< 50 or ≥ 65), female sex, non-Hispanic white race, higher income, rural area, and higher tumor burden were independently linked to iCCA diagnosis vs HCC. Among patients with primary liver cancer, the authors identified demographic, socioeconomic, and clinical factors that were associated with an iCCA diagnosis rather than HCC. Despite the fact that iCCA patients presented at an advanced stage, OS in the multivariable analysis was comparable between iCCA and HCC. For subgroups with poor prognostic features, iCCA was associated with a longer OS.