Iannaccone M, Barbero U, De Benedictis M, et al. - Since there exists limited data concerning the effect of bioresorbable polymer drug eluting stent (BP-DES) vs durable polymer drug eluting stent (DP-DES) among patients managed with percutaneous coronary intervention using ultrathin stents in left main or bifurcations, therefore, in order to address this topic, researchers examined patients with a ULM or bifurcation stenosis managed with percutaneous coronary intervention using ultrathin stents (struts thinner than 81 μm) in the RAIN registry. The rate of target lesion revascularization (TLR) was assessed as the primary endpoint. Experts compared patients managed with BP-DES vs DP-DES. Patients managed with BP-DES were shown to have better outcome in term of major adverse cardiovascular events and target vessel revascularization as well as a trend towards lower TLR, as revealed in sensitivity analysis of outcomes following a two-stents strategy. Overall, in this study sample, BP-DES appeared to perform similarly to DP-DES: experts suggested the likely potential value of the observed trends towards improved clinical results in those managed with the BP-DES, for the purpose of speculating the stent choice in selected high-risk subgroups of patients carrying an increased risk of ischemic events.