Aydın F, Çelikel E, Tekin ZE, et al. - In view of the recent recognition of multisystem inflammatory syndrome in children (MIS‐C) in association with coronavirus disease 2019 as a cytokine storm syndrome, researchers explored this cytokine storm syndrome by comparing the initial laboratory results of MIS‐C and macrophage activation syndrome (MAS). This analysis involved 13 MAS (9 boys, 4 girls) and 26 MIS‐C (16 boys,10 girls) cases. Lower hemoglobin (10.10 g/dL) and fibrinogen (2.72 g/dL) were detected in MAS patients, but these cases exhibited higher ferritin (17 863 mg/dL) and lactate dehydrogenase (LDH) (890.61 U/L) at the time of diagnosis. MIS‐C patients were found to have higher absolute neutrophil count (12 180/mm ³ ) and C‐reactive protein (194.23 mg/dL) values, but lower absolute lymphocyte count (1140/mm ³ ) at the time of diagnosis. Overall, a significant alteration in ferritin, hemoglobin, LDH, and fibrinogen levels was evident in MAS vs MIS‐C. However, the presence of more severe signs such as cardiac involvement was seen in patients with MIS‐C vs MAS.