Choi MJ, Kang M, Shin SY, et al. - The antiviral effect of hydroxychloroquine (HCQ) vs lopinavir/ritonavir (LPV/r) was determined in patients with COVID-19 via performing nationwide retrospective case-control study. Researchers included a total of 4,197 patients with mild-to-moderate COVID-19 and categorized them into three groups: LPV/r (n = 1,268), HCQ (n = 801), and standard care without HCQ or LPV/r (controls, n = 2128). Findings revealed similar SARS-CoV-2 viral shedding duration between HCQ and LPV/r groups. They indicated no benefit of either of the two in improving viral clearance compared with the control group.