Goffredo P, et al. - Researchers investigated the optimal management strategy, prognostic factors, and staging system for rectal squamous cell carcinoma via performing this population-based study. Patients ≥18 years of age undergoing radiation or local excision alone, radiation with local excision, or radiation with radical resection were identified using the Surveillance, Epidemiology, and End Results database. As per outcomes, they recommend considering a treatment approach primarily based on radiation as the optimal management strategy for rectal squamous cell carcinoma. Moreover, its prognosis seems to be more accurately made using a staging system based on size (American Joint Committee on Cancer-anus) rather than depth of invasion (American Joint Committee on Cancer-rectum).