Han Y, et al. - This study entailed comparison of the effects of a loading dose of dexmedetomidine (DEX) combined with propofol or sevoflurane on hemodynamics during anesthesia maintenance. Researchers found that significant increase in blood pressure was continued as a result of intraoperative administration of a loading dose of DEX combined with propofol in anesthesia maintenance. In contrast, when combined with sevoflurane, it didn’t produce increased blood pressure. Due to the known side effects of DEX, it was not unexpected that DEX combined with propofol or sevofurance decreased heart rate. Overall, exercising caution was recommended while using DEX during the entire intravenous anesthesia maintenance period, especially during maintenance with propofol.