Xu Y, et al. – The effectiveness of intravitreal conbercept and ranibizumab in the treatment of diabetic macular edema (DME) in a real–life clinical practice is compared. Both conbercept and ranibizumab are effective in the treatment of DME, achieving the similar clinical efficacy. In comparison to ranibizumab, conbercept demonstrates a longer treatment interval and that fewer intravitreal conbercept injections are required.